نThe effect of hydroalcoholic extract of ginger (zingiber officinale) on the lipid profile of male rats after receiving doxorubicin

Abstract Introduction: Doxorubicin leads to lipid profile disorders. The aim of this study was to evaluate the hydroalcoholic extract of ginger (zingiber officinale) on the lipid profile of male rats after receiving doxorubicin. Material and Methods: In this experimental study, 63 adult male rats were divided into 7 groups of 9: control group, sham group: received distilled water. Experimental group 1 received 20 mg / kg doxorubicin and experimental groups 2 and 3 received 300 and 600 mg / kg of hydroalcoholic extract of ginger, respectively. Experimental groups 5 and 4 received doxorubicin and hydroalcoholic extract of ginger (600 mg / kg + 600 mg / kg) mg / kg (300 mg / kg + 300 mg / kg), respectively. After the drug dose, blood samples were collected and serum levels of lipid profiles were measured. SPSS19 software, ANOVA and Tukey test were used for data analysis. Results: Serum levels of triglyceride, total cholesterol, and LDL cholesterol were significantly increased in the doxorubicin group compared to the control group. Serum HDL cholesterol levels in the doxorubicin group showed a significant decrease compared to the control group. Serum levels of triglycerides, total cholesterol, LDL cholesterol and HDL cholesterol in the groups (600 + 20 mg / kg) and 300 + 20 mg / kg) showed a significant decrease compared to the doxorubicin group (P <0.05). Conclusion: Ginger hydroalcoholic extract probably improved its lipid profile after receiving doxorubicin due to its antioxidant properties.